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Article

Global distribution and impact of knockdown resistance mutations in Aedes aegypti on pyrethroid resistance.

Parasites & vectors - 24 Sept 2025

Tognarelli Javier, Moya Pablo R, González Christian R, Collao-Ferrada Ximena

Abstract excerpt

The ongoing fight against mosquito-borne diseases such as dengue, Zika, and chikungunya is increasingly challenged by Aedes aegypti resistance to pyrethroid insecticides. This resistance is primarily driven by knockdown resistance (kdr) mutations in the voltage-gated sodium channel (Vgsc) gene, which have been identified in different regions with significant variability in their prevalence and impact. Managing...

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Topics

Animals
Aedes
Pyrethrins
Insecticide Resistance
Insecticides
Mutation
Mosquito Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Voltage-Gated Sodium Channels

Mosquito Control

Insect Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 40993808
DOI: 10.1186/s13071-025-06817-9
PMCID: PMC12462022

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