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Knockdown resistance in mosquito vectors: Molecular mechanisms, global spread, and future directions for sustainable vector control.

Molecular and biochemical parasitology - 1 Jun 2026

Godson S G Antony

Abstract excerpt

Pyrethroid insecticides remain central to malaria and dengue vector control programmes. However, their long-term effectiveness is increasingly threatened by knockdown resistance (kdr). kdr arises from mutations in the voltage-gated sodium channel (VGSC) gene, particularly within the IIS6 and IIIS6 domains, which reduce insecticide binding while preserving normal neuronal function. Key mutations include L1014...

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PMID: 41825782
DOI: 10.1016/j.molbiopara.2026.111740

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