Article
Pred-MutHTP: Prediction of disease-causing and neutral mutations in human transmembrane proteins.
Human mutation - 1 Mar 2020
Kulandaisamy A, Zaucha Jan, Sakthivel Ramasamy, Frishman Dmitrij, Michael Gromiha M
Abstract excerpt
Membrane proteins are unique in that segments thereof concurrently reside in vastly different physicochemical environments: the extracellular space, the lipid bilayer, and the cytoplasm. Accordingly, the effects of missense variants disrupting their sequence depend greatly on the characteristics of the environment of the protein segment affected as well as the function it performs. Because membrane proteins have...
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