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Article

Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression.

Journal for immunotherapy of cancer - 1 Jun 2021

Huang Richard S P, Decker Brennan, Murugesan Karthikeyan, Hiemenz Matthew, Mata Douglas A, Li Gerald, Creeden James, Ramkissoon Shakti H, Ross Jeffrey S

Abstract excerpt

BACKGROUND: The effects of non-amplification short variant (SV) mutations in CD274 (programmed death-ligand 1 (PD-L1)) on PD-L1 protein expression and immune checkpoint inhibitors (ICPIs) therapy are unknown. Here, we present a retrospective analysis of CD274 mutations detected by comprehensive genomic profiling (CGP) and correlate these results with tumor-cell PD-L1 immunohistochemistry (IHC)-based expression...

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Identifiers

PMID: 34130989
DOI: 10.1136/jitc-2021-002558
PMCID: PMC8207995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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