Article
In vitro exposure to clofazimine can select for delamanid and pretomanid resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 5 Nov 2025
Rupasinghe Praharshinie, Ismail Nabila, Mulders Wim, Warren Robin M, Joseph Lavania, Ngcamu Dumisani, Gwala Thabisile, Omar Shaheed V, Vereecken Jens, de Jong Bouke C, Rigouts Leen, Borroni Emanuele, Cirillo Daniela M, Schön Thomas, Miotto Paolo, Köser Claudio U
Abstract excerpt
In vitro experiments with Mycobacterium tuberculosis showed that clofazimine exposure selected for delamanid and pretomanid resistance and mutations in fbiA, fbiC, or fbiD-after the acquisition of Rv0678 mutations where this could be determined. Whether this is also possible in vivo and in an Rv0678 wild-type background has to be studied further. Based on the available evidence, however, we propose that...
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