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Article

Interaction between linezolid and Mycobacterium tuberculosis in an experimental in vitro model.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Apr 2011

Cremades Rosa, Rodríguez Juan Carlos, Garcia-Pachón Eduardo, Galiana Antonio, Ruiz-García Montserrat, López Pilar, Royo Gloria

Abstract excerpt

As linezolid is emerging as a useful alternative in the treatment of multi-resistant tuberculosis, we developed an in vitro model to elucidate certain aspects of the interaction that takes place between the microorganism and the antibiotic. We found that the drug does not generate resistant mutants following repeated exposure at subinhibitory concentrations and that it exhibits bactericidal activity against most...

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PMID: 21492231
DOI: 10.1111/j.1600-0463.2011.02735.x

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