Article
Adduct Formation of Delamanid with NAD in Mycobacteria.
Antimicrobial agents and chemotherapy - 21 Apr 2020
Hayashi Mikayo, Nishiyama Akihito, Kitamoto Ryuki, Tateishi Yoshitaka, Osada-Oka Mayuko, Nishiuchi Yukiko, Kaboso Shaban A, Chen Xiuhao, Fujiwara Mamoru, Inoue Yusuke, Kawano Yoshikazu, Kawasaki Masanori, Abe Tohru, Sato Tsutomu, Kaneko Kentaro, Itoh Kimiko, Matsumoto Sohkichi, Matsumoto Makoto
Abstract excerpt
Delamanid (DLM), a nitro-dihydroimidazooxazole derivative currently approved for pulmonary multidrug-resistant tuberculosis (TB) therapy, is a prodrug activated by mycobacterial 7,8-didemethyl-8-hydroxy 5-deazaflavin electron transfer coenzyme (F420)-dependent nitroreductase (Ddn). Despite inhibiting the biosynthesis of a subclass of mycolic acids, the active DLM metabolite remained unknown. Comparative liquid...
Topics
- Antitubercular Agents
- Chromatography, Liquid
- Drug Resistance, Multiple, Bacterial
- Isoniazid
- Mass Spectrometry
- Mycobacterium tuberculosis
- Mycolic Acids
- NAD
- NADH Dehydrogenase