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Article

Primary Clofazimine and Bedaquiline Resistance among Isolates from Patients with Multidrug-Resistant Tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jun 2017

Xu Jian, Wang Bin, Hu Minghao, Huo Fengmin, Guo Shaochen, Jing Wei, Nuermberger Eric, Lu Yu

Abstract excerpt

Clofazimine has been repurposed for the treatment of tuberculosis, especially for multidrug-resistant tuberculosis (MDR-TB). To test the susceptibility to clofazimine of Mycobacterium tuberculosis clinical isolates, MICs of clofazimine were determined using the microplate alamarBlue assay (MABA) method for 80 drug-resistant isolates and 10 drug-susceptible isolates for comparison. For five clofazimine-resistant...

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Identifiers

PMID: 28320727
DOI: 10.1128/AAC.00239-17
PMCID: PMC5444180

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