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Article

Recapitulating the clinical scenario of BRCA-associated pancreatic cancer in pre-clinical models.

International journal of cancer - 1 Jul 2018

Golan Talia, Stossel Chani, Atias Dikla, Buzhor Ella, Halperin Sharon, Cohen Keren, Raitses-Gurevich Maria, Glick Yulia, Raskin Stephen, Yehuda Daniel, Feldman Anna, Schvimer Michael, Friedman Eitan, Karni Rotem, Wilson Julie M, Denroche Robert E, Lungu Ilinca, Bartlett John M S, Mbabaali Faridah, Gallinger Steven, Berger Raanan

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. BRCA-associated PDAC comprises a clinically relevant subtype. A portion of these patients are highly susceptible to DNA damaging therapeutics, however, responses are heterogeneous and clinical resistance evolves. We have developed unique patient-derived xenograft (PDX) models from metastatic lesions of germline BRCA-mutated patients...

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Identifiers

PMID: 29396858
DOI: 10.1002/ijc.31292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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