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Article

Characterizing the mutational landscape of sinonasal squamous cell carcinoma using whole-exome sequencing.

Oral oncology - 1 Oct 2025

Vareta Jimmy A, Zhang Xiang, Kuhnell Damaris, Hagen Matthew C, Takiar Vinita, Wise-Draper Trisha M, Casper Keith A, Rodriguez-Ramirez Princess, Dragon Julie A, Langevin Scott M

Abstract excerpt

BACKGROUND: Sinonasal squamous cell carcinoma (SNSCC) accounts for less than 3% of all head and neck cancers. The 5-year overall survival rate ranges from 30 to 50%. While whole-exome sequencing (WES) studies have illuminated the mutational landscape of numerous cancer types, few systematic efforts have been conducted for SNSCC, leaving many common driver mutations in this malignancy largely unknown. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40972435
DOI: 10.1016/j.oraloncology.2025.107694
PMCID: PMC12690484

Genes

FNBP4
KMT2D
NOD1
NOTCH1
OR5C1
SCAND3
TP53
VWDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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