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Article

Astrocytic and microglial phenotypes in focal cortical dysplasia.

Epilepsy research - 1 Dec 2025

Goyal Aditi, Rao Shilpa, Philip Mariamma, Arivazhagan A, Saini Jitender, Vishwanathan L G, Asranna Ajay, K Raghavendra, Mundlamuri R C, Sadashiva Nishanth, Bharath R D, K Karthik, M Sandhya, Rao Malla Bhaskara, Sinha Sanjib, Mahadevan Anita

Abstract excerpt

BACKGROUND: Focal cortical dysplasia (FCD) is a common cause of focal epilepsy, however pathophysiology of epileptogenesis in FCD remains unresolved. Emerging evidence suggests that dysfunctional astrocytes are key players in epilepsy. Recently two phenotypes of astrocytes (A1/A2) and microglia (M1/M2) have been described in neurological diseases with neuroinflammatory and neuroprotective roles. We investigated...

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Identifiers

PMID: 40966840
DOI: 10.1016/j.eplepsyres.2025.107663

Genes

GBP2
CD14
CD163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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