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Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signatures

16 Aug 2023

Abstract excerpt

Focal cortical dysplasia (FCD) is a brain malformation that causes medically refractory epilepsy. FCD is classified into three categories based on structural and cellular abnormalities, with FCD type II being the most common and characterized by disrupted organization of the cortex and abnormal neuronal development. In this study, we employed cell-type deconvolution and single-cell signatures to analyze bulk...

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PMID: 37587190
DOI: 10.1038/s41598-023-40240-3

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