Article
Balloon cells promote immune system activation in focal cortical dysplasia type 2b.
Neuropathology and applied neurobiology - 1 Oct 2021
Zimmer Till S, Broekaart Diede W M, Luinenburg Mark, Mijnsbergen Caroline, Anink Jasper J, Sim Nam Suk, Michailidou Iliana, Jansen Floor E, van Rijen Peter C, Lee Jeong Ho, François Liesbeth, van Eyll Jonathan, Dedeurwaerdere Stefanie, van Vliet Erwin A, Mühlebner Angelika, Mills James D, Aronica Eleonora
Abstract excerpt
AIMS: Focal cortical dysplasia (FCD) type 2 is an epileptogenic malformation of the neocortex associated with somatic mutations in the mammalian target of rapamycin (mTOR) pathway. Histopathologically, FCD 2 is subdivided into FCD 2a and FCD 2b, the only discriminator being the presence of balloon cells (BCs) in FCD 2b. While pro-epileptogenic immune system activation and inflammatory responses are commonly...
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