Article
Association between the APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), and MMP1 (rs1799750) gene polymorphisms and lipodystrophy in people living with HIV receiving antiretroviral therapy.
Expert review of molecular diagnostics - 1 Nov 2025
Soares da Silva Andreia, Do Socorro de Mendonça Cavalcanti Maria, Furtado de Mendonça Belmont Taciana, de Alencar Ximenes Ricardo Arraes, da Nóbrega Débora Nascimento, Dos Santos Souza Roberta, Farias Isabela Cristina Cordeiro, Do Ó Kleyton Palmeira, Silva Vasconcelos Luydson Richardson, Diniz George Tadeu Nunes, de Barros Miranda Filho Demócrito
Abstract excerpt
BACKGROUND: The pathogenesis of lipodystrophy in people living with HIV (PLWHIV) receiving antiretrovirals appears to be multifactorial and may involve genetic factors; however, it is not yet fully understood. We verified the association between single nucleotide polymorphisms in the APOC3-rs2854116, ESR2-rs3020450, HFE-rs1799945 and MMP1-rs1799750 genes and lipodystrophy and its subtypes in PLWHIV receiving...