Article
Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART.
AIDS (London, England) - 2 Jan 2012
Gasparotto Aline S, Sprinz Eduardo, Lazzaretti Rosmeri K, Kuhmmer Regina, Silveira Jussara M, Basso Rossana P, Pinheiro Cezar A T, Silveira Mariângela F, Ribeiro Jorge P, Mattevi Vanessa S
Abstract excerpt
OBJECTIVE: To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and ) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. DESIGN:...