Article
The 1G/1G+1G/2G Genotypes of MMP1 rs1799750 Are Associated with Higher Levels of MMP-1 and Are Both Associated with Lipodystrophy in People Living with HIV on Antiretroviral Therapy.
AIDS research and human retroviruses - 1 May 2021
Silva Andreia Soares da, Cavalcanti Maria do Socorro de Mendonça, Belmont Taciana Furtado de Mendonça, Ximenes Ricardo Arraes de Alencar, Silva Aline Vieira da, Nóbrega Débora Nascimento da, Souza Roberta Dos Santos, Farias Isabela Cristina Cordeiro, do Ó Kleyton Palmeira, Vasconcelos Luydson Richardson Silva, Diniz George Tadeu Nunes, Miranda-Filho Demócrito de Barros
Abstract excerpt
In HIV-infected patients, antiretroviral therapy (ART) is associated to adipose tissue redistribution known as lipodystrophy (LD). This study aimed at verifying the association between the polymorphism of the MMP1 gene (rs1799750) (1G/2G) and the serum levels of matrix metalloproteinase 1 (MMP-1) with LD and its subtypes in people living with HIV on ART. This is a cross-secional study. LD was self-reported. The...
Topics
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- HIV Infections
- Humans