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In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease.

Lipids in health and disease - 30 Jan 2023

Patnaik Damini, Jena Atala Bihari, Kerry Rout George, Duttaroy Asim K

Abstract excerpt

BACKGROUND: Nonalcoholic fatty liver, or NAFLD, is the most common chronic liver ailment. It is characterized by excessive fat deposition in hepatocytes of individuals who consume little or no alcohol and are unaffected by specific liver damaging factors. It is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease, and sleep apnea. The global burden of NAFLD is...

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PMID: 36717943
DOI: 10.1186/s12944-023-01782-7
PMCID: PMC9885621

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