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Article

Distinct Chemical Cues Reprogram Cellular and Multicellular Phenotypes in Ovarian Cancer Spheroids.

Small (Weinheim an der Bergstrasse, Germany) - 1 Nov 2025

Sreepadmanabh M, Ganesh Meenakshi, Langthasa Jimpi, Bhat Ramray, Bhattacharjee Tapomoy

Abstract excerpt

The self-organization of cellular collectives is crucial in development and cancer. Multicellular aggregation in cancer is associated with a higher efficiency of metastasis. However, it is not fully understood how mechanochemical microenvironmental cues affect the organization and stability of such ensembles. Here, using a model system of ovarian cancer spheroids, which temporally transit from solid, dysmorphic...

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Identifiers

PMID: 40955874
DOI: 10.1002/smll.202506120
PMCID: PMC12590526

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