Article
Systematically quantifying morphological features reveals constraints on organoid phenotypes.
Cell systems - 20 Jul 2022
Beck Lauren E, Lee Jasmine, Coté Christopher, Dunagin Margaret C, Lukonin Ilya, Salla Nikkita, Chang Marcello K, Hughes Alex J, Mornin Joseph D, Gartner Zev J, Liberali Prisca, Raj Arjun
Abstract excerpt
Organoids recapitulate complex 3D organ structures and represent a unique opportunity to probe the principles of self-organization. While we can alter an organoid's morphology by manipulating the culture conditions, the morphology of an organoid often resembles that of its original organ, suggesting that organoid morphologies are governed by a set of tissue-specific constraints. Here, we establish a framework to...
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