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Article

Resistin-like molecule-β (RELM-β) targets airways fibroblasts to effect remodelling in asthma: from mouse to man.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 2015

Fang C L, Yin L J, Sharma S, Kierstein S, Wu H F, Eid G, Haczku A, Corrigan C J, Ying S

Abstract excerpt

BACKGROUND: RELM-β has been implicated in airways inflammation and remodelling in murine models. Its possible functions in human airways are largely unknown. The aim was to address the hypothesis that RELM-β plays a role in extracellular matrix deposition in asthmatic airways. METHODS: The effects of RELM-β gene deficiency were studied in a model of allergen exposure in mice sensitised and challenged with...

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PMID: 25545115
DOI: 10.1111/cea.12481
PMCID: PMC4769607

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