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Article

Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study.

Journal of Alzheimer's disease : JAD - 1 Nov 2025

Gu Hongpeng, Yu Kenan, Zhou Jiahua, Chu Bowei, Zhang Weizhong, Dong Jinliang, He Jikai

Abstract excerpt

BackgroundThe relationship between surgical approaches and postoperative cognitive dysfunction remains controversial.ObjectiveTo investigate the causal effect of cholecystectomy on dementia and its subtypes, and the mediating role of circulating lipid metabolites.MethodsUsing large-scale genome-wide association studies (GWAS), the causal effect of genetically proxied cholecystectomy (18,319 cases and 444,614...

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PMID: 40934096
DOI: 10.1177/13872877251376316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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