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Causality between Cholecystectomy, Blood Lipids, and Major Adverse Cardiac and Cerebrovascular Events: A Multimodal Approach Highlighting Lipid Regulation.

Bulletin of experimental biology and medicine - 1 Nov 2025

Duan Juan, Yang Ti, Zhang Shengming, Zeng Deqin, He Yifeng

Abstract excerpt

Cholecystectomy alters lipid profiles and is associated with the risk of major adverse cardiac and cerebrovascular events (MACCE), yet the results are ambiguous. To assess the causal effects of cholecystectomy on blood lipid levels and risks of MACCE, we performed Mendelian randomization (MR) aiming to reduce confounding. We used genetic data on gallbladder removal, lipid levels, and MACCE from public databases....

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PMID: 41706273
DOI: 10.1007/s10517-026-06583-3

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LPL

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Causality between Cholecystectomy, Blood Lipids, and Major Adverse Cardiac and Cerebrovascular Events: A Multimodal Approach Highlighting Lipid Regulation.PMID 41706273Read ↗

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