Article
Prevalence of loss-of-function FTO mutations in lean and obese individuals.
Diabetes - 1 Jan 2010
Meyre David, Proulx Karine, Kawagoe-Takaki Hiroko, Vatin Vincent, Gutiérrez-Aguilar Ruth, Lyon Debbie, Ma Marcella, Choquet Helene, Horber Fritz, Van Hul Wim, Van Gaal Luc, Balkau Beverley, Visvikis-Siest Sophie, Pattou François, Farooqi I Sadaf, Saudek Vladimir, O'Rahilly Stephen, Froguel Philippe, Sedgwick Barbara, Yeo Giles S H
Abstract excerpt
OBJECTIVE: Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity. We aimed to determine whether FTO mutations are dispro...
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