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A Reverse Genetics Approach To Study Feline Infectious Peritonitis

6 Apr 2012

Abstract excerpt

Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence...

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Identifiers

PMID: 22491466
DOI: 10.1128/jvi.00023-12

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