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Article

Novel mutation N588 residue in the NS1 protein of feline parvovirus greatly augments viral replication.

Journal of virology - 14 May 2024

Li Lisha, Liu Zirui, Liang Rui, Yang Mengfang, Yan Yuanyuan, Jiao Yuzhou, Jiao Zhe, Hu Xiaoshuai, Li Mengxia, Shen Zhou, Peng Guiqing

Abstract excerpt

Feline parvovirus (FPV) infection is highly fatal in felines. NS1, which is a key nonstructural protein of FPV, can inhibit host innate immunity and promote viral replication, which is the main reason for the severe pathogenicity of FPV. However, the mechanism by which the NS1 protein disrupts host immunity and regulates viral replication is still unclear. Here, we identified an FPV M1 strain that is regulated by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38591899
DOI: 10.1128/jvi.00093-24
PMCID: PMC11092363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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