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Heterogeneity in Phenotype and Early Metabolic Response to Lifestyle Interventions in Type 2 Diabetes in China Using a Tree-Like Representation.

Diabetes - 1 Nov 2025

Ding Yi, Zhou Qi, Jiang Youjin, Cao Qiuyu, Wu Xianglin, Li Xiaoran, Xu Yu, Lu Jieli, Xu Min, Wang Tiange, Zhao Zhiyun, Chen Yuhong, Liu Yan, Li Jie, Ning Guang, Wang Weiqing, Bi Yufang, Li Mian

Abstract excerpt

Deciphering the heterogeneity of type 2 diabetes in prognosis and treatment effect is essential. We used a novel dimensionality reduction approach to describe the type 2 diabetes phenotype continuum and visualize the difference in lifestyle intervention efficacy in Chinese patients. Based on 17,816 participants with newly diagnosed type 2 diabetes (aged ≥40 years) from a nationwide cohort, 12 key phenotypes were...

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PMID: 40906542
DOI: 10.2337/db25-0197

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