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Article

Mapping phenotypic heterogeneity and cardiometabolic risk in obesity using a tree-based dimensionality reduction framework.

Journal of translational medicine - 14 Feb 2026

Zhao Yan, Wang Weihao, Wang Zihao, Ma Jing, Zhang Jia, Shao Jian, Zhou Kaixin, Pan Qi, Nie Zedong, Xu Guogang, Guo Lixin

Abstract excerpt

BACKGROUND: The population-level heterogeneity of obesity has yet to be systematically investigated. We aimed to apply the data dimensionality reduction tree (DDRTree) method to obese individuals and to examine how distinct phenotypic patterns align with different outcomes. METHODS: To characterize the heterogeneity of obesity, a two-dimensional (2D) tree structure based on the DDRTree algorithm was employed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41691272
DOI: 10.1186/s12967-026-07867-y
PMCID: PMC13011527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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