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Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

5 Feb 2021

Abstract excerpt

Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant...

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PMID: 33547301
DOI: 10.1038/s41467-020-20870-1

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