Article

Ferrapoptosis: Discovery of a Hybrid Programmed Cell Death

2025-11-27

Abstract excerpt

<h4>ABSTRACT</h4> Traditional taxonomies classify ferroptosis and apoptosis as distinct forms of regulated cell death. Here, we challenge this view by defining and validating a previously unrecognized neuronal death entity in traumatic brain injury (TBI), which we term “Ferrapoptosis”. This hybrid mode of death is characterized by the coexistence of ferroptotic and apoptotic molecular and ultrastructural features...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff538fc9-7939-5ef3-860a-1f621249f87c
DOI: 10.1101/2025.11.25.690347

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ferrapoptosis: Discovery of a Hybrid Programmed Cell DeathDOI 10.1101/2025.11.25.690347Read

Regulated cell death: discovery, features and implications for neurodegenerative diseasesSemantic proximity Read

Unraveling cell death mechanisms in traumatic brain injury: dynamic roles of ferroptosis and necroptosisSemantic proximity Read

The Silent Saboteur: How Mitochondria Shape the Long-Term Fate of the Injured BrainSemantic proximity Read

Neuronal cell death in nervous system development, disease, and injury (Review)Semantic proximity Read

Mitochondrial Mechanisms of Neuronal Cell Death: Potential TherapeuticsSemantic proximity Read

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injurySemantic proximity Read

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous SystemSemantic proximity Read

Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approachesSemantic proximity Read

Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative DiseaseSemantic proximity Read

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury.Semantic proximity Read

Forms of Non-Apoptotic Cell Death and Their Role in Gliomas—Presentation of the Current State of KnowledgeSemantic proximity Read

Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain InjurySemantic proximity Read