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Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA

27 Jun 2020

Abstract excerpt

Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). Integration of HBV DNA into the human genome may contribute to oncogenesis and to the production of the hepatitis B surface antigen (HBsAg). Whether integrations contribute to HBsAg levels in the blood is poorly known. Here, we characterize the HBV RNA profile of HBV integrations in liver tissue in patients with chronic HBV infection,...

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PMID: 32592629
DOI: 10.1111/jvh.13356

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