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Article

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B.

Gut - 1 Dec 2021

Svicher Valentina, Salpini Romina, Piermatteo Lorenzo, Carioti Luca, Battisti Arianna, Colagrossi Luna, Scutari Rossana, Surdo Matteo, Cacciafesta Valeria, Nuccitelli Andrea, Hansi Navjyot, Ceccherini Silberstein Francesca, Perno Carlo Federico, Gill Upkar S, Kennedy Patrick T F

Abstract excerpt

OBJECTIVE: The involvement of HBV DNA integration in promoting hepatocarcinogenesis and the extent to which the intrahepatic HBV reservoir modulates liver disease progression remains poorly understood. We examined the intrahepatic HBV reservoir, the occurrence of HBV DNA integration and its impact on the hepatocyte transcriptome in hepatitis B 'e' antigen (HBeAg)-negative chronic hepatitis B (CHB). DESIGN: Liver...

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Share to DNA, Viral
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

Share to Hepatitis B virus

Share to Hepatocytes

Share to Transcriptome

Share to Viremia

Source

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Identifiers

PMID: 33402415
DOI: 10.1136/gutjnl-2020-323300
PMCID: PMC8588301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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