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HBV-Integration Studies in the Clinic: Role in the Natural History of Infection

26 Feb 2021

Abstract excerpt

Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV covalently closed circular DNA (cccDNA) is essential for viral replication and the establishment of a persistent infection. Integrated HBV DNA represents another stable form of viral DNA regularly observed in the livers of infected...

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PMID: 33652619
DOI: 10.3390/v13030368

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