Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injury

Abstract excerpt

Introduction: Sepsis, particularly sepsis-induced liver injury (SLI), exhibits acute onset and high mortality (up to 80%). While murine models are widely used for mechanistic studies due to limited human sample availability, their accuracy in replicating human SLI pathophysiology remains debated. Methods: Human SLI transcriptomes were characterized to identify core genes and immune signatures using Venn analysis...

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• Acute Kidney Injury Research
• Immune Response and Inflammation
• Liver Disease and Transplantation