Article

Immunogenomic Landscape of B cells in Patients with Septic Shock

2024-10-15

Abstract excerpt

<title>Abstract</title> <p>Background. B cells play a critical role in protecting against infections. Decreased cell number, altered phenotype and function were found in B cells from patients with sepsis/septic shock, however, the underlying molecular mechanisms were not elucidated. In the present study, we aimed to explore the B cells composition, gene expressions and B cell receptor (BCR) characterization in p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe131a75-5c55-517f-9f3c-34352f30758f
DOI: 10.21203/rs.3.rs-4896171/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunogenomic Landscape of B cells in Patients with Septic ShockDOI 10.21203/rs.3.rs-4896171/v1Read

Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in PatientsSemantic proximity Read

Single-cell transcriptomics reveals the alteration of peripheral blood mononuclear cells driven by sepsisSemantic proximity Read

Unveiling Dynamic Changes and Regulatory Mechanisms of T Cell Subsets in Sepsis PathogenesisSemantic proximity Read

Age-related dysregulation of B cells in acute respiratory distress syndromeSemantic proximity Read

Using RNA-Seq to Investigate Immune-Metabolism Features in Immunocompromised Patients With SepsisSemantic proximity Read

Analysis of novel biomarkers and immune cell alterations in sepsis based on single-cell sequencing and machine learning algorithmsSemantic proximity Read

A Meta-Analysis of Whole Blood Transcriptome Reveals Association of Increased Neutrophil Activity and T cell Suppression in SepsisSemantic proximity Read

Role of plasma and blood-cell co-metagenomic sequencing in precise diagnosis and severity evaluation of sepsis, a prospective cohort study in sepsis patientsSemantic proximity Read

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortiumSemantic proximity Read

Investigating immune dysregulation and hub genes in septic cardiomyopathy developmentSemantic proximity Read

Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illnessSemantic proximity Read

Bulk RNA Sequencing With Integrated Single-Cell RNA Sequencing Identifies BCL2A1 as a Potential Diagnostic and Prognostic Biomarker for SepsisSemantic proximity Read