Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells

26 Mar 2025

Abstract excerpt

Macrophages play a critical role in the development of sepsis-induced acute lung injury (si-ALI), with extracellular vesicles (EVs) acting as crucial mediators. However, the effects and mechanisms of macrophage-derived EVs on si-ALI remain unclear. This study demonstrated that macrophage-derived EVs induce endothelial ferroptosis and barrier disruption during sepsis. Through proteomic sequencing and reanalysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to Ferroptosis and cancer prognosis
Share to Inflammatory Biomarkers in Disease Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40156957
DOI: 10.1016/j.redox.2025.103614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cellsPMID 40156957Read ↗

BACTERIAL EXTRACELLULAR VESICLES IN THE REGULATION OF INFLAMMATORY RESPONSE AND HOST-MICROBE INTERACTIONSSemantic proximity Read ↗

Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patientsSemantic proximity Read ↗

Extracellular Vesicles: New Players in the Mechanisms of Sepsis- and COVID-19-Related ThromboinflammationSemantic proximity Read ↗

Pulmonary extracellular vesicles drive alveolar macrophage dysfunction via microRNA transfer in Acute Respiratory Distress SyndromeSemantic proximity Read ↗

Screening of novel disease genes of sepsis-induced myocardial Disfunction by RNA sequencing and bioinformatics analysisSemantic proximity Read ↗

Role of Extracellular microRNAs in Sepsis-Induced Acute Lung InjurySemantic proximity Read ↗

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomicsSemantic proximity Read ↗

Complement receptor CD35 on single urinary extracellular vesicle as novel biomarker of sepsis-associated acute kidney injurySemantic proximity Read ↗

Revealing the regulatory mechanism of FSP1 and N4-acetylcytosine in sepsis-induced acute lung injury by integrating multi-omics dataSemantic proximity Read ↗

Mitophagy and Ferroptosis in Sepsis-Induced ALI/ARDS: Molecular Mechanisms, Interactions and Therapeutic Prospects of Medicinal PlantsSemantic proximity Read ↗

Identification of ferroptosis-related genes in male mice with sepsis-induced acute lung injury based on transcriptome sequencingSemantic proximity Read ↗

Low-dose Olaparib improves septic cardiac function by reducing ferroptosis via accelerated mitophagy fluxSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.