Article
Whole-genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia.
HGG advances - 15 Jan 2026
Li Runjia, Gagliano Taliun Sarah A, Liao Kevin, Flickinger Matthew, Sobell Janet L, Genovese Giulio, Locke Adam E, Chiu Rebeca Rothwell, LeFaive Jonathon, Wang Jiongming, Martins Taylor, Chapman Sinéad, Neumann Anna, Handsaker Robert E, Arnett Donna K, Barnes Kathleen C, Boerwinkle Eric, Braff David, Cade Brian E, Fornage Myriam, Gibbs Richard A, Hoth Karin F, Hou Lifang, Kooperberg Charles, Loos Ruth J F, Metcalf Ginger A, Montgomery Courtney G, Morrison Alanna C, Qin Zhaohui S, Redline Susan, Reiner Alexander P, Rich Stephen S, Rotter Jerome I, Taylor Kent D, Viaud-Martinez Karine A, Bigdeli Tim B, Gabriel Stacey, Zollner Sebastian, Smith Albert V, Abecasis Goncalo, McCarroll Steve A, Pato Michele T, Pato Carlos N, Boehnke Michael, Knowles James, Kang Hyun Min, Ophoff Roel A, Ernst Jason, Scott Laura J
Abstract excerpt
In studies of individuals of primarily European genetic ancestry, common and low-frequency variants and rare coding variants have been found to be associated with the risk of bipolar disorder (BD) and schizophrenia (SZ). However, less is known for individuals of other genetic ancestries or the role of rare non-coding variants in BD and SZ risk. We performed whole-genome sequencing (∼27X) of African American...
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