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Article

A Prominent Pro-Inflammatory Phenotype Is Observed in Replication and Stress-Induced Senescent Mast Cells.

Aging cell - 1 Oct 2025

Ibarra-Sánchez A, Madera-Salcedo I, Esparza-Reyes D, Mendoza-Montiel P, Padilla J, González-Espinosa C

Abstract excerpt

Mast cells (MC) are long-lived important immune effectors that control inflammation, allergies, and innate immunity reactions, but the expression of specific markers in replicative and stress-induced senescence in this cell type, together with its relevance in vivo, has not been described. Here, bone marrow-derived MCs (BMMC) were generated from young C57BL6/J mice and kept in culture for a long time or treated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40875511
DOI: 10.1111/acel.70186
PMCID: PMC12507405

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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