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Article

Investigation of genetic variants and causal biomarkers associated with brain aging.

Scientific reports - 27 Jan 2023

Kim Jangho, Lee Junhyeong, Nam Kisung, Lee Seunggeun

Abstract excerpt

Delta age is a biomarker of brain aging that captures differences between the chronological age and the predicted biological brain age. Using multimodal data of brain MRI, genomics, and blood-based biomarkers and metabolomics in UK Biobank, this study investigates an explainable and causal basis of high delta age. A visual saliency map of brain regions showed that lower volumes in the fornix and the lower part of...

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PMID: 36707530
DOI: 10.1038/s41598-023-27903-x
PMCID: PMC9883521

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