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Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study

3 Mar 2025

Abstract excerpt

Sleep disorders (SDs) are a common issue in the elderly. Epigenetic clocks based on DNA methylation (DNAm) are now considered highly accurate predictors of the aging process and are associated with age-related diseases. This study aimed to investigate the causal relationship between sleep traits and the epigenetic clock using Mendelian randomization (MR) analysis. The genome-wide association study (GWAS)...

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PMID: 40032851
DOI: 10.1038/s41598-024-84957-1

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