Article
Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.
The Journal of biological chemistry - 7 Aug 2009
Ortega Ximena, Silipo Alba, Saldías M Soledad, Bates Christa C, Molinaro Antonio, Valvano Miguel A
Abstract excerpt
Burkholderia cenocepacia is an opportunistic pathogen that displays a remarkably high resistance to antimicrobial peptides. We hypothesize that high resistance to antimicrobial peptides in these bacteria is because of the barrier properties of the outer membrane. Here we report the identification...
Topics
- Animals
- Burkholderia
- Carbohydrate Sequence
- Cell Line
- Cloning, Molecular
- Drug Resistance, Bacterial
- Humans
- Lipopolysaccharides
- Mice
- Molecular Sequence Data
- Mutation
- Oligosaccharides
- Plasmids
- Polymyxin B