Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload

28 Jul 2025

Abstract excerpt

The present findings establish an S100A8/A9-related axis between myeloid cells and cardiac cells that drives the pressure overload-induced transition from hypertrophy to HF, suggesting that S100A8/A9 is a promising therapeutic target for this disease.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to S100 Proteins and Annexins
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40860162
DOI: 10.7150/thno.118369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overloadPMID 40860162Read ↗

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.Semantic proximity Read ↗

Genomic and RNA-Seq profiling of patients with HFrEF unraveled OAS1 mutation and aggressive expression.Semantic proximity Read ↗

Genomic and RNA-Seq Profiling of Patients with Heart Failure Identified Alterations in Phosphorylation and Immune Signaling PathwaysSemantic proximity Read ↗

Alternative splicing in mechanically stretched podocytes as a model of glomerular hypertensionSemantic proximity Read ↗

RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failureSemantic proximity Read ↗

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axisSemantic proximity Read ↗

Helix-Loop-Helix Protein p8, a Transcriptional Regulator Required for Cardiomyocyte Hypertrophy and Cardiac Fibroblast Matrix Metalloprotease InductionSemantic proximity Read ↗

The long non-coding RNA NEAT1 regulates the transcriptional landscape of cardiomyocytesSemantic proximity Read ↗

Global Profile of tRNA-Derived Small RNAs in Pathological Cardiac Hypertrophy Plasma and Identification of tRF-21-NB8PLML3E as a New Hypertrophy SuppressorSemantic proximity Read ↗

Global Profile of tRNA-Derived Small RNAs in Pathological Cardiac Hypertrophy Plasma and Identification of tRF-21-NB8PLML3E as a New Hypertrophy MarkerSemantic proximity Read ↗

Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.Semantic proximity Read ↗

Heart-enriched long noncoding RNA NPPA-AS1 regulates pathological cardiac hypertrophy by initiating a EP300-GATA4 axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.