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Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid

25 Aug 2025

Abstract excerpt

Anti-pituitary-specific transcription factor (PIT)−1 hypophysitis is an autoimmune disease characterized by hormone secretion impairment from PIT-1-expressing pituitary cells, accompanied by malignancies with ectopic PIT-1 expression. Cytotoxic T cells (CTL) targeting PIT-1-positive cells have been implicated in disease development, yet direct evidence is lacking. As human leukocyte antigen (HLA)-matching is...

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PMID: 40855071
DOI: 10.1038/s41467-025-63183-x

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