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Article

NLRC5 p.Pro191Leu as a genetic susceptibility factor in anti-PIT-1 hypophysitis.

Journal of endocrinological investigation - 1 Sept 2026

Urai Shin, Bando Hironori, Yamamoto Masaaki, Iguchi Genzo, Takahashi Yutaka

Abstract excerpt

PURPOSE: Anti-PIT-1 hypophysitis is a rare T cell-mediated autoimmune pituitary disorder presenting as a paraneoplastic syndrome or after immune checkpoint inhibitor (ICI) therapy, and its predominance in Japan suggests an underlying genetic predisposition. The NLR family CARD domain containing 5 (NLRC5) encodes a key transcriptional regulator of major histocompatibility complex (MHC) class I, and its p.Pro191Leu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42189480
DOI: 10.1007/s40618-026-02926-z
PMCID: PMC13498477

Genes

NLRC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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