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Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity.

Stem cell research - 1 Dec 2020

Chu Edward Po-Fan, Lin Chia-Hung, Cho Candy Hsin-Hua, Cheng I-Fen, Kuo Tzu-Chien, Chen Ruei-Ying, Liao Chia-Nan, Cheng Jen-Chien, Tsai Jason Isheng, Wang Po-Chuan, Chang Shing-Jyh, Shen Chia-Ning

Abstract excerpt

Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells. Genetic studies have identified > 60 T1D risk loci that harbor genes with disease-causative alleles. However, determining the biological effects of such loci is often difficult due to limited tissue availability. Disease-specific human induced pluripotent stem cells (hiPSCs) are a valuable resource for modeling T1D...

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PMID: 33096384
DOI: 10.1016/j.scr.2020.102029

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