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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

1 Jul 2020

Abstract excerpt

Understanding the root causes of autoimmune diseases is hampered by the inability to access relevant human tissues and identify the time of disease onset. To examine the interaction of immune cells and their cellular targets in type 1 diabetes, we differentiated human induced pluripotent stem cells into pancreatic endocrine cells, including β cells. Here, we describe an in vitro platform that models features of...

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PMID: 32668238
DOI: 10.1016/j.celrep.2020.107894

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