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Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage.

Brain tumor pathology - 1 Jan 2020

Ogawa Kaoru, Kurose Akira, Kamataki Akihisa, Asano Kenichiro, Katayama Kosuke, Kurotaki Hidekachi

Abstract excerpt

Giant cell glioblastoma (GC-GBM) consists of large cells with pleomorphic nuclei. As a contrast to GC-GBM, we defined monotonous small GBM (MS-GBM) as GBM that consists of small cells with monotonous small nuclei, and compared the DNA damage as well as other pathological features. GC-GBM showed minimal invasion (< 2 mm) and focal sarcomatous areas. TERTp was wild type in GC-GBM but mutant in MS-GBM. OLIG2...

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Identifiers

PMID: 31655917
DOI: 10.1007/s10014-019-00355-w
PMCID: PMC7028818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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