Article
IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation.
Acta neuropathologica communications - 24 Dec 2021
Barresi Valeria, Simbolo Michele, Mafficini Andrea, Martini Maurizio, Calicchia Martina, Piredda Maria Liliana, Ciaparrone Chiara, Bonizzato Giada, Ammendola Serena, Caffo Maria, Pinna Giampietro, Sala Francesco, Lawlor Rita Teresa, Ghimenton Claudio, Scarpa Aldo
Abstract excerpt
Giant cell glioblastoma (GC-GBM) is a rare variant of IDH-wt GBM histologically characterized by the presence of numerous multinucleated giant cells and molecularly considered a hybrid between IDH-wt and IDH-mutant GBM. The lack of an objective definition, specifying the percentage of giant cells required for this diagnosis, may account for the absence of a definite molecular profile of this variant. This study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.