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Article

Unraveling the Immunogenetics of STAT Proteins: Clinical Perspectives on Gain-of-Function and Loss-of-Function Variants.

Asian Pacific journal of allergy and immunology - 1 Jun 2024

Meesilpavikkai Kornvalee, Hirankarn Nattiya, Dalm Virgil A S H, Hagen P Martin van, Dik Willem A, IJspeert Hanna

Abstract excerpt

Signal Transducer and Activator of Transcription (STAT) proteins play pivotal roles in immune regulation. The dysregulation of these proteins, attributed to both gain-of-function (GOF) and loss-of-function (LOF) variants, has emerged as a substantial and intricate area of research. This comprehensive review delves into the intricate details of the diverse clinical spectrum associated with STAT variants and the...

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Identifiers

PMID: 38710647
DOI: 10.12932/AP-270124-1776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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