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Chemotherapy and Stem Cell Transplantation Increase p16 INK4a Expression, a Biomarker of T-cell Aging

24 Aug 2016

Abstract excerpt

The expression of markers of cellular senescence increases exponentially in multiple tissues with aging. Age-related physiological changes may contribute to adverse outcomes in cancer survivors. To investigate the impact of high dose chemotherapy and stem cell transplantation on senescence markers in vivo, we collected blood and clinical data from a cohort of 63 patients undergoing hematopoietic cell...

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PMID: 27591832
DOI: 10.1016/j.ebiom.2016.08.029

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