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Article

Uric Acid Disrupts Heart Development in Zebrafish by Inhibiting the Wnt Signaling Pathway.

Cardiovascular toxicology - 1 Nov 2025

Li Yahong, Yang Peiying, Wang Xin, Zhang Zhilei, Jiang Tao, Sun Yun, Xu Zhengfeng

Abstract excerpt

Congenital heart disease (CHD) is the most common birth defect and involves intricate developmental mechanisms. Uric acid (UA), the final metabolite of purine degradation in humans, has a largely unexplored role in heart development. This study investigated the effects of elevated UA levels-both exogenous and endogenous-on cardiac development in a zebrafish model and explored the involvement of Wnt signaling in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40839160
DOI: 10.1007/s12012-025-10053-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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